Adaptol (Mebicar) belongs to the group of anxiolytic drugs. It has a moderate tranquilizing effect, reduces or eliminates the feeling of anxiety, fear, anxiety, irritability, emotional stress.

It is close in chemical structure to the natural metabolites of the body - its molecule consists of two methylated urea fragments that are part of the bicyclic structure.

Adaptol acts on the activity of structures included in the limbic-reticular complex, in particular, on the emotiogenic zones of the hypothalamus, and also has an effect on all 4 major neurotransmitter systems: GABA-, choline-, serotonin- and adrenergic, contributing to their balance and integration, but does not have a peripheral adrenoceptor blocking effect.

In addition to the sedative, it has a nootropic effect. Adaptol improves cognitive functions, attention and mental performance without stimulating the symptoms of productive psychopathological disorders - delirium, pathological emotional activity.

It does not reduce mental and motor activity, does not contribute to the development of drowsiness and does not affect the rate of reactions, which allows the use of this drug even in the daytime and while driving a car. It is prescribed for neurosis, pain manifestations in the heart, not associated with angina pectoris, in stressful conditions, during menopause.

After oral administration, it is well absorbed from the gastrointestinal tract (77-80%). Cmax of the active substance in blood plasma is reached 0.5 hours after taking the drug. A high concentration of the active substance persists for 3-4 hours, then gradually decreases. About 55-70% of the dose taken is excreted from the body with urine, the rest - with feces unchanged during the day.

Adaptol are white or almost white tablets, round, flat-cylindrical, with a chamfer and a risk mark.

Indications for use

What helps Adaptol? The drug is prescribed in the following cases:

• neuroses and neurosis-like states (irritability, emotional instability, anxiety and fear);
• to improve the tolerance of antipsychotics and tranquilizers in order to eliminate the somatovegetative and neurological side effects caused by them;
• cardialgia of various origins (not associated with coronary artery disease);
• nicotine withdrawal (as part of complex therapy as a means of reducing craving for tobacco smoking).

Adaptol is used as the main remedy for nervous disorders of varying severity.

Instructions for use Adaptol and dosage

Taken orally, regardless of food intake. The standard dosage is 500 mg 2-3 times a day.

• The largest single dosage is 3 g, daily - 10 g.
• The duration of the course of treatment - from several days to 2-3 months.

In complex therapy, as a means of reducing the craving for tobacco smoking, 500-1000 mg 3 times a day for 5-6 weeks.

In pediatric practice, Adaptol is prescribed for children from 18 years of age (according to the instructions), the other is only at the discretion of the doctor! There is evidence of the use of this drug in the treatment of overactive bladder in children older than 7 years.

The duration of treatment of the child and the dosage of the drug is determined individually by the doctor. In most cases, 300-500 mg is prescribed, with an average of 250 mg 1-3 times a day.

Perhaps the simultaneous use of Adaptol with neuroleptics, tranquilizers (benzodiazepines), hypnotics, antidepressants and psychostimulants.

Side effects

According to doctors, in most cases, the course of treatment is well tolerated, due to the fact that the active ingredient is close to natural metabolites in its chemical structure.

In some cases, the following side effects are possible:

• allergic reactions;
• skin itching;
• lowering blood pressure;
• dyspeptic phenomena (disorders of the stomach, malfunctions of the digestive system);
• decrease in body temperature (at high doses);
• bronchospasm;
• dizziness;
• weakness.

In cases of hypotension and / or a decrease in body temperature (body temperature may drop by 1-1.5 ° C), discontinuation of the drug is not required. Blood pressure and body temperature normalize on their own within a few days.

Use during pregnancy

It has good penetration into all tissues of the body. Clinical studies on the appointment of Adaptol to pregnant and lactating mothers have not been conducted. Not recommended for use during pregnancy and lactation.

Contraindications

The only contraindication to the appointment of Adaptol is hypersensitivity to the components of the drug.

In addition, this is pregnancy and children under 18 years of age.

Overdose

Does not have toxic properties in case of overdose. Manifestations of severe poisoning are not registered.

When taking very large doses, they wash the stomach and prescribe detoxifying agents.

Analogues Adaptol, list of drugs

If you need to replace Adaptol, you can use the list of analogues according to the ATX code:

1. Anvifen,
2. mebicar,
3. Thezaneph.

When choosing analogues, it is important to understand that the instructions for use of Adaptol, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

The price of Adaptol in Russian pharmacies starts from 657 rubles per pack.

Store in a dry place, out of the reach of children, at a temperature not exceeding +25°C. Shelf life - 4 years. It is released in pharmacies by prescription.

Which is better - Adaptol or Grandaxin?

Grandaxin belongs to the group of benzodiazepine derivatives and has an anxiolytic effect on the body, while not having a sedative, anticonvulsant effect.

In general, its effect on the body is similar to the effect that Adaptol has. Which drug to prefer, the doctor will tell, based on the specific situation.

Neurologists, psychiatrists and conventional clinical psychologists often prescribe the new drug Adaptol to their patients. What is it and is it safe...

"Adaptol": instructions for use for children and adults, composition, analogues and reviews

By Masterweb

11.04.2018 14:00

The modern world is full of stress and anxiety. Chronic fatigue and depression have become the number one problem in the last decade. People try to save themselves by hobbies: sports, sewing, modeling, looking for ways to escape from the oppressive reality. But most often this path ends in the chair of a psychotherapist. Neurologists, psychiatrists and conventional clinical psychologists often prescribe the new drug Adaptol to their patients. What is it and is it safe to use for chronic stress and depression?

Tranquilizers in medicine

This is an extensive class of drugs, to which Adaptol belongs. Modern tranquilizers are completely safe and non-addictive. The most common indications for their appointment:

• unmotivated anxiety;
• poor sleep and nightmares;
• psychosis and irritability;
• chronic alcoholism and drug addiction;
• vegetative-vascular dystonia;
• panic attacks;
• psychosomatic disorders;
• premenstrual syndrome in women;
• other emotional disorders.

"Adaptol": instructions for use

It is a tablet form of a new generation tranquilizer. It has a mild sedative, sedative, relaxing effect on the body. The first weeks of admission causes a slight defocusing of attention - patients should be more careful while driving, and it is better to completely avoid activities associated with high concentration.

"Adaptol" has an average tranquilizing activity. Weakens anxiety, phobias, anxiety, fear, internal emotional stress. "Adaptol" has an effect on the four main neurotransmitters - GABA, choline, serotonin and adrenergic, contributing to their balance and integration. It does not cause peripheral adrenonegative effects.

Active ingredient: one tablet contains 300 mg of mebicar (tetramethyltetraazabicyclooctanedione).

Auxiliary components: methylcellulose, calcium stearate.

Indications for taking Adaptol tablets

Neurologists, psychotherapists and psychiatrists write a prescription for the drug for complaints of the following diseases and symptoms:

• neuroses and neurosis-like states;
• phenomena of irritability, bursts of aggression, emotional instability, anxiety and fear;
• severe course of premenstrual syndrome in women;
• psychosomatic disorders of various etiologies;
• with various phobias of a chronic nature;
• to improve the tolerability of neuroleptics, to eliminate the somatovegetative side effects caused by them;
• with cardialgia of various etiologies;
• with a delay in psycho-speech development in children and adolescents;
• with early childhood autism;
• attention deficit hyperactivity disorder;
• with withdrawal and post-abstinence syndromes characteristic of the period of refusal of ethanol-containing drinks for people with chronic alcoholism;
• in complex therapy as a means of reducing the craving for tobacco smoking.

"Adaptol": it is an antidepressant or tranquilizer

Many patients are sure that this drug belongs to the class of antidepressants. This opinion is wrong. In fact, Adaptol is a tranquilizer. Many people have a prejudice against this class of drugs. Reviews of doctors and the instructions of "Adaptol" confirm that this is a soft and modern drug. The prejudice against him is not justified.

Despite this, patients often refuse to take it. Upon learning that the drug belongs to the class of tranquilizers, a phobia appears. Modern cinema and literature have instilled the view that tranquilizers have a strong effect on the psyche and cognitive functions of the brain. Allegedly, a person "becomes stupid" and turns into a "vegetable". Such beliefs represent complete ignorance! For decades, medicine has not used drugs that can even slightly lead to a violation of the cognitive abilities of the brain. "Adaptol" is prescribed even to children and adolescents - clinical trials have confirmed that this is a completely safe tranquilizer.

Cost and terms of purchase

Packaging will cost about 500-600 rubles, depending on the region and the markup of the pharmacy chain. The box contains two blisters, each containing ten tablets. The rather high cost is justified by the complexity of the extraction of the main active substance.

The instruction to "Adaptol" warns about the possibility of buying only on prescription from the attending physician. However, many unscrupulous pharmacies are selling without regulatory documents. So it is quite possible to purchase "Adaptol" without a prescription - but in this case, the unfortunate patient himself will be responsible for the side effects.

Overdose symptoms

The instruction to "Adaptol" suggests a dosage of 500 mg (1 tablet) 2-3 times a day. Take regardless of food - both during meals and on an empty stomach, this does not affect the result. The maximum single dose for adults is 3 g (6 tablets), and the daily dose is 5 g (10 tablets).

With nicotine addiction or during the period of withdrawal symptoms in chronic alcoholism, the recommended dose is 600-900 mg three times a day for ten weeks.

Dose titration has not been studied in patients with chronic renal failure. In this disease, the drug must be used with caution.

Symptoms of an overdose of the drug are expressed in the following symptoms:

• tremor, nervousness, nervous tics;
• dyspeptic disorders (heartburn, belching, feeling of fullness in the abdomen, diarrhea);
• drowsiness, feeling tired and wanting to lie down;
• distracted attention;
• indigestion, diarrhea;
• mild dysphoria.

Contraindications to taking "Adaptol"

You should not start taking if there is at least one of the following health deviations:

• suicidal tendencies and manifestations of outbreaks of aggression (admission is possible only in a hospital, under the supervision of a doctor);
• chronic renal failure;
• pressure surges, arrhythmia, cardiomyopathy of various origins;
• allergy to the active substance;
• chronic liver diseases: hepatosis, hepatitis of various etiologies (reception is possible only after consulting a doctor).

Medicamentous preparations-analogues of "Adaptol"

We can advise the following drugs with a sedative, sedative, mild antidepressant effect on the body:

• "Afabazole" is a fairly safe medicine, as it is taken, it accumulates an effect on the body. It has a sedative, mild hypnotic effect.
• "Cerebrolysin", "Cogitum", "Cortexin" are modern nootropics. The principle of action of these drugs is different than that of Adaptol. But they also have a calming, mild hypnotic effect, remove irritability and nervousness.
• "Lazeya", "Mebikar" - are also included in the class of tranquilizers. According to the chemical structure, the main active ingredient of these drugs is similar to Adaptol. In terms of action on the nervous system, they are almost completely identical.

Instructions and reviews for analogues of "Adaptol" should be carefully read before starting the reception. You should not arbitrarily prescribe such drugs to yourself and drink them without the supervision of a doctor.

Appropriateness for children and adolescents

Often, neurologists prescribe Adaptol to children with hyperactivity, autism, developmental delays, and various kinds of psychopathy. Studies have shown that the drug does not lead to defects and disruption of the internal organs. Nor is it the cause of cognitive impairment. So if the doctor has prescribed Adaptol to your child, you can safely start taking it. Children, as a rule, are recommended small dosages - from 200 mg per day.

Patients taking adaptol tablets give reviews from extremely negative - they say "dummy", to the most delicious - this is a panacea for nerves. Let's try to figure out where the truth about this drug lies.

Adaptol composition.

The medicine Adaptol has the active substance mebicar. There is also a drug of the same name "Mebikar" with the same effect, which is 2-3 times cheaper than adaptol. That is, the question of whether it is better to take Adaptol or Mebicar does not make sense. Adaptol is produced in Latvia (a country in the eurozone), and we have mebicar, that is, 3 times cheaper.
Mebicar was based on urea, a natural end product of protein metabolism in the human body. Therefore, all talk about the toxicity of the drug to the liver does not correspond to reality. Studies have shown that its toxicity is 150 times less than benzodiazepine tranquilizers such as diazepam or phenazepam.

How does the adapter work?

Its mechanism of action is as follows. He, as experts suggest, increases the amount of serotonin in the structures of the brain, which enhances the processes of inhibition in the central nervous system. It is a drug of central action. It has no effect on the peripheral parts of the nervous system. Its action is more similar to that of antidepressants such as Paxil and Prozac. There are no long-term results of the drug use yet.

Adaptol contraindications.

Adaptol during pregnancy and breastfeeding patients is contraindicated. Adaptol can be used in children, as the instructions say, from the age of 10. These limitations exist because there have been no clinical trials of the drug in pregnant women and children. It's a very tricky question. Although many doctors prescribe this medicine to children much younger than 10 years old and pregnant women, based on the very low toxicity of the drug.
It enhances the effect of various sedative psychotropic and hypnotic drugs. Therefore, care must be taken in complex treatment with these drugs.
Adaptol and alcohol are incompatible. Like any tranquilizer, adaptol enhances the effect of alcohol, which can lead to unpredictable consequences. You need to stop taking the medicine a couple of days before drinking alcohol, because you will get drunk several times faster.

Adaptol indications.

Adaptol belongs to the group of tranquilizers, but is not, as mentioned above, a derivative or "relative" of benzodiazepines (phenazepam, etc.). It has a tranquilizing effect - reduces fear, anxiety and anxiety. It does this without relaxing the muscles and reducing attention, so it belongs to daytime tranquilizers. In addition, it has a nootropic (improving the functioning of brain cells), antioxidant (antioxidant), cerebroprotective (protection of brain cells) and other beneficial effects on the human body.
Adaptol is used for various moderate neuroses and anxiety disorders, which are accompanied by anxiety and fear.
In addition, the drug normalizes the reduced level of endogenous (produced inside the body) alcohol in the blood. Therefore, it is used in the treatment of alcoholism and smoking.

Adaptol addictive.

The question that most interests all patients with VVD and panic disorder. I want to put everyone at ease. The drug does not cause addiction and drug dependence. Therefore, adaptol withdrawal syndrome is absent. But still, like any drug that has a tranquilizing effect, it must be canceled gradually, gradually reducing the dosage over the course of a week.

Adaptol application.

How to take adaptol? Taking the drug does not depend on food intake. The dosage of the drug also has wide limits, which is associated with the low toxicity of the drug - 1-2 tablets 2-3 times a day.
How long can you take adaptol? The treatment period is from several weeks to several months. A single dose of the drug is also possible and effective. The action of the drug begins 15-30 minutes after ingestion and lasts 3-4 hours.
In reality, a smooth calming effect occurs after 30 minutes. The drug has a beneficial effect on sleep only with moderate anxiety - the patient sleeps better, there are no nightly awakenings and nightmares.

Adaptol side effects

The drug is very bitter in taste, so you need to drink it with a sufficient amount of water. This strong bitterness sometimes leads to disorders of the gastrointestinal tract - up to and including vomiting. An unpleasant sensation of bitterness remains in the mouth for about an hour after taking the medicine.
Adaptol can lower blood pressure and body temperature. Therefore, it is undesirable to take it to patients with low blood pressure, as well as when driving a car, because of the danger of losing consciousness from a sharp decrease in pressure. Although it is considered a daytime tranquilizer, it causes daytime sleepiness in the first week of use.
This condition does not require treatment. The pressure and body temperature are restored on their own after the drug is canceled and removed, and drowsiness disappears after a week - the body gets used to it.

Adaptol for panic attacks.

The tranquilizing effect of this drug is very weak, most patients practically do not feel it on themselves. Patients often ask:

What to take adaptol or afabazole, adaptol or atarax?

What is better adaptol or afabazole?

How to replace adaptol?

All these drugs have a very weak tranquilizing effect, so there is not much difference between them. Except for the fact that they have different active ingredients, and atarax, in addition to other side effects, causes drowsiness and general weakness. This also includes such popular drugs as Novo-Passit and Nervocheel.

The effectiveness of the drug in treatment depends on the severity and stage of development of the VVD, as well as the amount present. These medicines help with moderate anxiety, irritability and restlessness, without the presence of panic attacks.

Adaptol, like the drugs listed above, is practically useless when the patient has regular panic attacks. Here we need stronger tranquilizers of the benzodiazepine series.

This is the biggest mistake in the treatment of VVDshnikov. They are afraid to use phenazepam and other stronger tranquilizers, for fear that there will be a tranquilizer withdrawal syndrome. And the further use of adaptol leads to a loss of time and aggravation of the symptoms of VVD.

It is not the withdrawal syndrome of tranquilizers that should be feared, but the worsening of the IRR, against the background of insufficient treatment with drugs with a weak tranquilizing effect.

Due to the weakness of the tranquilizing action, adaptol is useless during a panic attack. There is no point in taking it when the PA attack has begun, because its effect will begin only when the PA is in full swing, and maybe it will already begin to pass (after 15-30 minutes). It is better to take it regularly in complex treatment for the prevention of PA attacks.
Each patient has a very individual reaction to this drug. For some, it suits and improves the condition, while for others it either does not help at all, or, conversely, causes deterioration. Therefore, it is necessary to independently make a decision about further medication.

"Adaptol" refers to representatives of the class of tranquilizers that can be used to eliminate anxiety, restlessness and emotional arousal. In pharmacies, the drug is dispensed in the form of white tablets, on which there is a risk. What reviews, contraindications and side effects does Adaptol have?

Compound

The main active ingredient in the structure of the drug isdione. Available "Adaptol" in the form of tablets for oral administration (500 milligrams). Additional trace elements are the following components:

• cellulose ether and methanol;
• salt of calcium and stearic acid.

Action spectrum

The chemical composition of the drug is close to the natural components that are produced by the body. The main point of action of the drug is the limbic-reticular complex. In addition, according to the instructions, Adaptol tablets affect four mediator systems:

• serotonin;
• adrenalin;
• cholinergic system;
• gamma-aminobutyric acid.

The drug does not have a peripheral blocking effect, namely, it does not lower blood pressure due to the process of relaxation of the muscle layer of the vascular wall.

According to the reviews of patients who took Adaptol, the drug instantly eliminates anxiety symptoms, irritability, anxiety, and emotional overstrain. At the same time, the normalization of the emotional background is not accompanied by a failure in the coordination of movements, as well as muscle relaxation.

"Adaptol" does not reduce mental activity, and also does not affect the indicators of coordination of movements. Because of this, the drug can be used by both students and working citizens.

This tranquilizer does not provoke a feeling of euphoria or unreasonable fun in the patient.

The active substance in the composition of monotherapy does not have a hypnotic effect, but when taken simultaneously with other sedative drugs, it reduces their effect.

The constant use of the drug can completely eliminate or to a greater extent alleviate the symptoms of nicotine abstinence.

According to the instructions and reviews of doctors, "Adaptol" increases attention, performance.

After a single dose of the drug, the active substance is absorbed in the digestive system by eighty percent. At the same time, the maximum content of the active trace element in the blood is fixed after thirty minutes and persists for four hours.

About half of the accepted dosage of the drug binds to red blood cells, the rest is in a free state.

Indications

"Adaptol" is prescribed for use in the presence of the following conditions and deviations, for example:

1. Neuroses (functional disorders of higher nervous activity of psychogenic origin).
2. Emotional instability (a mental illness characterized by loss of control).
3. Fear (negatively colored emotion that occurs in response to danger or threat).
4. Anxiety (a negative emotion that expresses a feeling of uncertainty, a bad feeling).
5. Irritability (an emotional state that is characterized by an acute feeling of disappointment or annoyance).
6. Cardialgia (a pathological condition characterized by the occurrence of pain in the left side of the chest).
7. VSD during menopause (a polyetiological syndrome characterized by dysfunction of the autonomic nervous system).
8. Relief of symptoms of nicotine addiction.

How to take medicine correctly?

"Adaptol" in tablet form should be taken orally at five hundred milligrams (one tablet) two to three times a day, depending on the severity of the symptoms. In this case, the duration of therapy can vary from a couple of days to several months.

As a drug that can reduce the symptoms of abstinence, "Adaptol" should be taken orally from five hundred to a thousand milligrams (one to two capsules) three times a day, the duration of treatment is twenty-one days.

According to the instructions for use of "Adaptol" it is known that the capsules can be taken regardless of food. In most cases, patients are recommended to use from three hundred to five hundred milligrams of the active ingredient two to three times a day.

The drug is prescribed for a period of two days to three months, depending on the diagnosis and the characteristics of the course of the disease. Instructions for use for the drug indicates that the maximum single dosage of the active substance is three grams, the maximum daily dosage is ten grams. In the treatment of nicotine addiction, the drug is prescribed at a dosage of 0.9 grams three times a day.

The medication may adversely affect the ability to drive a car, as it can cause weakness and dizziness (due to low blood pressure). The use of "Adaptol" is recommended to be canceled in the event of allergic manifestations in the form of skin itching or skin rashes.

As a rule, the drug is well tolerated by patients. The drug is practically non-toxic, but with a significant increase in dosage, it can cause an increase in side effects:

1. Hypotension (a prolonged state of the body, characterized by low blood pressure).
2. Dizziness.
3. Migraine (a neurological disease, the most common and characteristic symptom of which is episodic or regular severe pain).
4. Dyspeptic disorders (functional disorders of the digestive system).

At what age is it allowed to take?

According to the instructions for use, taking the drug before the age of eighteen is not recommended. This is due to the lack of information about the reactions of children to this medicine. But many doctors allow the appointment of this drug in pediatrics, if there are grounds for such an appointment.

In this case, the minimum age of the patient who is prescribed "Adaptol", as a rule, is from nine to ten years. For children aged eight years, six years or younger, even experienced doctors do not recommend the medicine, because the reaction to the medicine in babies is unpredictable. For example, the use of "Adaptol" at bedtime in conjunction with antipsychotics can cause sleep apnea, which threatens the life of the baby at night.

In addition, the child's kidneys or liver may not be able to cope with such a drug. And although the drug is noted for excellent tolerability, the likelihood of negative manifestations before the age of ten years is very high. If "Adaptol" was prescribed by an experienced pediatrician, then any reactions of the child's body will be under his control.

Contraindications

Like any other drug, Adaptol has a number of prohibitions on use, for example:

1. Hypersensitivity to substances in the drug.
2. An interesting position of a woman.
3. Breast-feeding.

Overdose

Even with a constant increase in the dosage of the drug, Adaptol was determined to be of low toxicity, since no situations of severe poisoning were recorded. Sometimes weakness, low blood pressure, and dizziness may occur.

"Adaptol": compatibility

The drug can be used as part of complex treatment with other tranquilizers, as well as neuroleptics and antidepressants.

Negative reactions

In most cases, therapy with the Adaptol drug is well tolerated, due to the fact that the main trace element is close to natural molecules (in its chemical structure), present in all cells of the body and necessary for life.

In addition, it is important to be careful when using the drug "Adaptol" in the presence of a person with chronic diseases of the liver and kidneys, with low blood pressure.

Do not take alcoholic beverages while taking medication. This combination can cause a drop in blood pressure (up to fainting), as well as the appearance of heaviness in the head. There is evidence that after drinking strong drinks while taking Adaptol, problems developed in the work of the central nervous system, which were manifested by loss of orientation in space and memory disorders.

Sharing "Adaptol" with alcohol can lead to vegetovascular dystonia and the occurrence of panic attacks. In rare situations, alcohol provokes the neutralization of the effects of the drug. From the foregoing, we can conclude that it is better not to drink alcohol during therapy with Adaptol.

Side effects of "Adaptol" are rarely recorded. Sometimes the following symptoms may appear:

1. Allergic reactions.
2. Dizziness.
3. Bronchospasm (a pathology that occurs when the muscles of the bronchi are activated and their lumen is reduced).
4. Weakness.
5. Decrease in body temperature below the standard (thirty-five degrees).
6. Skin itching.
7. Decrease in arterial blood pressure.
8. Malfunctions of the gastrointestinal tract.

Peculiarities

Sometimes when using the drug there are side effects ("Adaptol"), the body temperature may drop below the standard. At the same time, you should not stop stopping therapy, since this phenomenon disappears after a few days without the use of complex treatment. "Adaptol" is not addictive or addictive.

During therapy, work that requires increased attention should be avoided. "Adaptol" is released in pharmacies only with a prescription from the attending doctor.

Unlike other substitute drugs, the drug does not have a hypnotic effect. Due to this property, the use of "Adaptol" is allowed during the day.

"Adaptol": analogues

Like any other drug, Adaptol has substitutes, for example:

1. "Mebix".
2. Alprazolam.
3. "Elzepam".
4. "Gidazepam".
5. "Afobazol".
6. "Phenazepam".
7. "Elenium".
8. "Phenibut".
9. Stresam.
10. "Noofen".
11. "Sibazon".
12. "Tenotin".
13. "Anvifen".
14. "Mebicar".
15. "Amizil".
16. "Grandaxin".

The cost of "Adaptol" is 500 rubles.

Which remedy is more effective - "Adaptol" or "Afobazol"?

In addition to Adaptol, there are medicines on the therapeutic market with a different chemical composition, but with a similar spectrum of action. These drugs include "Afobazol", which can be purchased at the pharmacy without a doctor's prescription. The main action of "Afobazole" is an anti-anxiety effect along with a stimulating substance.

At the same time, "Afobazol" does not have a pronounced sedative and hypnotic effect. The drug is effective in that it does not provoke withdrawal syndrome, and also does not affect memory and attention. In terms of the severity of the therapeutic effect, these two drugs are approximately on the same level.

In addition, these drugs require a course of administration and are practically ineffective as drugs for emergency care. As for the harmful effects, they rarely occur with both drugs, mainly when the doses recommended by the doctor are not observed. Otherwise, the drugs are well tolerated, even with prolonged treatment. Since medicines with an anxiolytic effect are taken only as prescribed by a medical specialist, the choice of medicine depends on the recommendations of the doctor.

Active substance : mebicar
Each tablet contains 300 mg mebicar.
Excipients : methylcellulose, calcium stearate.

Pharmacotherapeutic group

Other anxiolytics.
ATX code: N05BX.

Pharmacological properties

Pharmacodynamics
The active substance of the drug Adaptol is close in chemical structure to the natural metabolites of the body - its molecule consists of two methylated urea fragments that are part of the bicyclic structure. Let's easily dissolve in water and in many organic solvents. Adaptol is chemically inert, does not interact with acids, alkalis, oxidizing and reducing agents, various drugs and food components. Adaptol acts on the activity of structures included in the limbic-reticular complex, in particular, on the emotiogenic zones of the hypothalamus, and also has an effect on all 4 major neurotransmitter systems - GABA, choline, serotonin and adrenergic, but does not have a peripheral adrenonegative effect. Adaptol eliminates or reduces anxiety, anxiety, fear, internal emotional stress and irritability. The calming effect of the drug is not accompanied by muscle relaxation and impaired coordination of movements. The drug does not reduce mental and motor activity, so Adaptol can be used during the working day or study. The drug does not create high spirits, a feeling of euphoria. It does not have a hypnotic effect, but enhances the effect of hypnotics and improves the course of sleep in case of its disturbances.
Pharmacokinetics
The active substance of the drug Adaptol is well (77-80%) absorbed from the gastrointestinal tract, up to 40% of the dose taken is bound by erythrocytes. The rest does not bind to plasma proteins and is in the plasma in a free form, so the active substance is freely distributed throughout the body and freely overcomes cell membranes. The maximum concentration of the active substance in the blood is reached 0.5 hours after taking the drug and the high level persists for 3-4 hours, then gradually decreases. 55-70% of the dose taken is excreted from the body with urine, the rest - with feces unchanged during the day.
The active substance of the drug is not metabolized and does not accumulate in the body.

Indications for use

Somatoform dysfunction of the autonomic nervous system and other neurotic disorders.

Dosage and administration

Adaptol is taken orally, regardless of the meal.
adults take 300-600 mg 2-3 times a day.
The maximum single dose is 3 g, the highest daily dose is 10 g.
The duration of the treatment course is from several days to 2-3 months.
Elderly patients do not need to reduce the dose.
Patients with liver failure dose reduction is not required.
At patients with renal insufficiency dose adjustment has not been studied. In these patients, the drug should be administered with caution.
Data on the safety and efficacy of Adaptol in children and adolescents under the age of 18 missing.

Side effects

Adaptol, like all medicines, can cause side effects that may not affect everyone.
The frequency of side effects according to the MedDRA classification system (Medical Dictionary of Regulatory Terminology):
Very common (≥1/10);
Frequent (≥1/100 to<1/10);
Uncommon (≥1/1000 to<1/100);
Rare (≥1/10,000 to<1/1000);
very rare (<1/10 000);
Unknown (cannot be determined from available data).
Immune System Disorders: unknown - hypersensitivity (hypersensitivity).
Nervous System Disorders: rare - dizziness; unknown - headache.
Cardiovascular disorders: rare - lowering blood pressure.
Gastrointestinal disorders: rare - dyspeptic disorders (expressed as a feeling of bitterness in the mouth, nausea, vomiting, abdominal pain, diarrhea).
Skin and subcutaneous tissue disorders: allergic reactions (angioedema, swelling of the eyelids, swelling of the face, swelling of the lips, swelling of the tongue, rash, papular rash, itching, erythema, urticaria, swelling of the skin), hyperhidrosis.
In the event of an allergic reaction, the drug should be discontinued.
Respiratory, thoracic and mediastinal disorders: unknown - bronchospastic reactions, an attack of bronchospasm. .
H kidney and urinary tract disorders: unknown - polyuria, nocturia (frequent urination at night).
General disorders: rare - decrease in body temperature, weakness; unknown - chest pain, swelling of the extremities, localized edema.
Metabolic and nutritional disorders: unknown - loss of appetite.
A decrease in blood pressure and / or a decrease in body temperature (body temperature may drop by 1-1.5 ° C) is not a reason for discontinuing the drug. Blood pressure and body temperature return to normal after the end of the course of treatment.
In the event of adverse reactions, including those not listed in this leaflet, you must stop taking the drug and consult a doctor.

Contraindications

Hypersensitivity to the active substance or to excipients of the drug.

Overdose

The drug is of low toxicity. Two reports of cases of overdose have been received. A single dose of the drug in a suicide attempt at a dose of 30 g did not lead to the development of a lethal outcome.
Treatment: in case of overdose, conventional detoxification methods are carried out, including gastric lavage, and symptomatic therapy.
The specific antidote is not known.

Precautionary measures

Isolated reports of cases of acute hypersensitivity reactions (hypersensitivity) have been received.

The use of the drug during pregnancy and lactation

The active substance penetrates well into all tissues and body fluids. Adequately controlled clinical studies of the use of the drug during pregnancy and lactation are not available, so prescribing the drug is not recommended.