Diphenhydramine instructions for use, intramuscular injections. "Diphenhydramine" for children: instructions for use. Interaction with other medicinal products

In case of acute pain symptoms with a high temperature, which is not knocked down by other antipyretic compounds, injections can be made with an analgin solution with diphenhydramine. The effectiveness of medicines in a pair is higher, and they are considered ideal. A double injection can be injected for adults and children. But starting in 2010, pediatricians began to negatively view these injections. Our specialists will tell you what purposes and contraindications are there for a double injection: analgin and diphenhydramine.

Why are the drugs effective in combination?

Thanks to the combination of active ingredients, analgin + diphenhydramine is effective in several directions at once: analgesic, antipyretic, decongestant, anti-inflammatory and anti-allergic action.

The absorption of medicines is high, and the effect on the patient's body is long-lasting (up to 6 hours). The high efficiency of the injection makes it possible to use the composition in the most severe cases.

Solution components

Analgin is a pyrazoline-based analgesic. Relieves pain spasms of various origins. Pharmacology is available in the form of pills and solution. An injection is given intramuscularly or intravenously. Absorption in injections is faster and more effective.

Diphenhydramine is an antihistamine with a pronounced anti-inflammatory effect. It can be purchased in the form of pills and solution, only with a doctor's prescription.

Analgin and diphenhydramine are excreted in the urine, every other day.

In what cases can contraindications be used?

In combination, the solution is used to relieve symptoms:

• prolonged fever associated with viral or bacterial diseases;
• pathologies of varying severity with pain syndromes;
• burns, headaches, muscle pains.

Solution is contraindicated for patients with diseases:

• asthma and acute forms of an allergic reaction;
• heart failure;
• kidney disease;
• neurology of varying severity.

Side effects are associated with the wrong dosage of the medication and injections performed at home, without the recommendation of a doctor.

Dosing by age

In case of pain and high temperature, analgin with diphenhydramine can be used in combination in the form of pills or injections.

We do not recommend giving an injection to a small child without a doctor, since the baby may have an individual intolerance to the solution.

It is better to make a solution intramuscularly, since the gastrointestinal tract is not damaged and the components begin to act faster. There are norms for a ready-made composition: For an adult and a child from 10 years old 1-2 ml / 2 times in 24 hours, for a young child, from 3 years old for 10 kg of weight 0.2 ml. But in aggregate no more than 1 ml.

Before the injection, carefully recalculate the patient's weight and mg of the solution, otherwise you can cause irreparable harm to the patient. It is better for the child to try to remove the temperature with suppositories or other drugs before injecting the solution.

1 ml of solution contains

active substance: diphenhydramine hydrochloride in terms of 100% substance 10 mg,

excipient: water for injection.

Description

Transparent colorless liquid.

Pharmacotherapeutic group

Systemic antihistamines. Aminoalkyl ethers. Diphenhydramine.

ATX code R06AA02

Pharmacological properties

Pharmacokinetics

Plasma protein binding - 98-99%. Most of it is metabolized in the liver, less is excreted unchanged in the urine within 24 hours. The half-life (T1 / 2) is 1-4 hours. It is well distributed in the body, penetrates the blood-brain barrier.
It is metabolized mainly in the liver by hydroxylation and conjugation to glucuronides; biotransformation products are eliminated in the urine. It is excreted in mother's milk and may cause sedation in infants. The maximum activity develops after 1 hour, the duration of action is from 4 to 6 hours.

Pharmacodynamics

The 1st generation H1-histamine receptor blocker eliminates the effects of histamine, which are manifested through this type of receptor. The effect on the central nervous system is due to the blockade of the H3-histamine receptors in the brain and the inhibition of the central cholinergic structures. Has a pronounced antihistamine activity, reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue edema, itching and hyperemia. It causes the effect of local anesthesia (when taken orally, there is a short-term numbness of the mucous membranes of the oral cavity), blocks the cholinergic receptors of the ganglia (lowers blood pressure) and the central nervous system, has sedative, hypnotic, antiparkinsonian and antiemetic effects. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions in inflammation and allergies than to systemic ones, i.e. lowering blood pressure. However, with parenteral administration to patients with a deficit in circulating blood volume, a decrease in blood pressure and an increase in the existing hypotension due to ganglion blocking action are possible. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the EEG and can provoke an epileptic seizure. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine), and to a lesser extent in bronchospasm of an allergic nature. The sedative and hypnotic effects are more pronounced with repeated doses.

Indications for use

Anaphylactic shock, urticaria, hay fever, angioedema, allergic conjunctivitis, drug-related allergic reactions

Hemorrhagic vasculitis (capillarotoxicosis)

Serum sickness

Itchy dermatoses, itching

Meniere's disease

Polymorphic exudative erythema

Postoperative vomiting

Method of administration and dosage

The drug is prescribed for adults intramuscularly and intravenously. Do not administer the drug subcutaneously due to irritant effect. With intramuscular administration, a single dose is 10-50 mg (1-5 ml), the maximum single dose is 50 mg (5 ml), the highest daily dose- 150 mg (15 ml). Intravenously, the drug should be administered drip at a dose of 20-50 mg (2-5 ml) of Diphenhydramine in 100 ml of 0.9% sodium chloride solution. The duration of treatment depends on the achieved effect and the tolerability of the drug.

Side effects

From the side nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, decreased speed of psychomotor reactions, anxiety, increased excitability, fear of death, irritability, nervousness, insomnia, euphoria, confusion, tremor, neuritis, convulsions, paresthesia, dilated pupils, increased intraocular pressure, visual impairment, diplopia, acute labyrinthitis, tinnitus. In patients with local brain lesions or epilepsy, convulsive discharges on the EEG are activated (even with the use of low doses of Diphenhydramine) and the drug can provoke an epileptic seizure.
From the side of the cardiovascular system: arterial hypotension, palpitations, tachycardia, extrasystole.
From the side of the blood system: agranulocytosis, thrombocytopenia, hemolytic anemia.
From the digestive tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, pain in the epigastric region, vomiting, diarrhea, constipation.
From the side genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation.

On the part of the respiratory system: dryness of the mucous membrane of the nose and throat, nasal congestion, thickening of the bronchial secretions, a feeling of compression in chest, shortness of breath, shortness of breath.
On the part of the skin and its derivatives: hyperemia, itching, polymorphic rashes, cyanosis of the skin and mucous membranes.

Allergic reactions: rash, urticaria, anaphylactic shock.

Reactions at the injection site: local necrosis with subcutaneous and intradermal administration.
Others: increased sweating, chills, fever, hyperthermia syndrome, photosensitivity.

Contraindications

Angle-closure glaucoma even in Kazakhstan is in UTI

Hyperplasia of the prostate

Stenosing ulcer of the stomach and duodenum

Cervical stenosis Bladder

Epilepsy

Bronchial asthma

Pregnancy and lactation

Hypersensitivity to the drug

Children's and adolescence under 18 years old

Pheochromocytoma

Congenital prolonged QT syndrome or long-term drug use that can prolong the QT interval

Bradycardia

Violation of the rhythm of the heart

Porphyria

Drug interactions

Diphenhydramine potentiates the effects of anesthetics, hypnotics, sedatives, narcotic analgesics and local anesthetics. When used with tricyclic antidepressants, it is possible to enhance the anticholinergic and inhibitory effect on the central nervous system. There is a risk of seizures when used with analeptics. Simultaneous use inhibitors of MAO and diphenhydramine can lead to an increase in blood pressure, as well as affect the central nervous and respiratory systems. The use of diphenhydramine together with antihypertensive drugs can increase the feeling of fatigue. The drug enhances the effect of ethanol, reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Should not be administered concurrently with preparations containing diphenhydramine, including for topical use.

Incompatibility. Do not mix with other medicines in the same container. Use only recommended solvent.

special instructions

Not recommended for subcutaneous administration. Since Diphenhydramine has an atropine-like effect, it should be used with caution in patients with a history of recent respiratory diseases (including asthma), the same history, I am not now a specific disease of increased intraocular pressure, with hyperthyroidism, diseases of the cardiovascular system, arterial hypotension. It can worsen the course of obstructive pulmonary diseases, severe diseases of the cardiovascular system, ileus, a condition with obstruction of the biliary tract. Diphenhydramine can cause lethargy, as well as cause agitation and hallucinations, convulsions, especially in case of an overdose. Use with caution in patients aged 60 years and older because of the greater likelihood of dizziness, sedation and arterial hypotension.

Prescribe with caution to patients with impaired liver and kidney function.
During treatment, UV radiation and alcohol consumption should be avoided. Patients need to inform the doctor about the use of this drug: the antiemetic effect can complicate the diagnosis of appendicitis and the recognition of symptoms of overdose with other drugs.

Features of the effect of the drug on the ability to manage vehicle or potentially dangerous mechanisms

Since diphenhydramine has sedative and hypnotic effects, during treatment with the drug, one should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Dosage Form: & nbspSolution for intravenous and intramuscular administration. Compound:

1 ml contains:

active substance: diphenhydramine hydrochloride (diphenhydramine) - 10 mg excipient: water for injection.

Description: Transparent colorless liquid. Pharmacotherapeutic group:Antiallergic agent (H1-histamine receptor blocker) ATX: & nbsp

R.06.A.A.02 Diphenhydramine

Pharmacodynamics:

First generation H1 histamine receptor blocker. The effect on the central nervous system is due to the blockade of H3 - histamine and m-cholinergic receptors in the brain. Relieves spasm of smooth muscles (direct action), reduces capillary permeability, prevents and weakens allergic reactions, has local anesthetic, antiemetic, sedative effects, has a hypnotic effect. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions in inflammation and allergies than to systemic ones, i.e. lowering blood pressure. However, with parenteral administration to patients with a deficit in circulating blood volume, a decrease in blood pressure and an increase in the existing hypotension are possible due to the ganglion blocking action. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic seizure. The action develops within a few minutes, lasting up to 12 hours.

Pharmacokinetics:

After intravenous and intramuscular administration, it is widely distributed in the body. The highest concentration is determined in the lungs, spleen, kidneys, liver, brain, muscles. Penetrates the blood-brain barrier (BBB). Binds to plasma proteins by 98-99%. It is metabolized mainly in the liver, partly in the lungs and kidneys. It is excreted from tissues after 6 hours. The half-life is 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and can cause sedation in infants (there may be a paradoxical reaction characterized by excessive excitability).

Indications: Anaphylactic and anaphylactoid reactions (in combination therapy); Quincke's edema, serum sickness, other acute allergic conditions (in combination therapy and in cases where the use of the tablet form is impossible). Contraindications:

Hypersensitivity, lactation period, angle-closure glaucoma, prostatic hyperplasia, stenosing peptic ulcer of the stomach and duodenum, bladder neck stenosis, bronchial asthma, epilepsy, children under 7 months of age.

Carefully:In view of the atropine-like effect of diphenhydramine, it should be used with caution in patients with a history of recent respiratory diseases (including asthma), increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, hypotension. Use with caution at the age of 60 years and older, due to the high probability of dizziness, sedation and hypotension. Pregnancy and lactation:

The use of diphenhydramine during pregnancy is possible only under the strict supervision of a physician when the intended benefit to the mother outweighs the potential risk to the fetus.

During treatment, breastfeeding should be discontinued.

Method of administration and dosage:

Intravenous and intramuscular.

For adults and children over 14 years old - 1-5 ml of 1% solution (10-50 mg) 1-3 times a day; the maximum daily dose is 200 mg.

For children aged 7 months to 12 months - 0.3-0.5 ml (3-5 mg), from 1 year to 3 years - 0.5-1 ml (5-10 mg), from 4 up to 6 years old - 1-1.5 ml (10-15 mg), from 7 to 14 years old - 1.5-3 ml (15-30 mg), if necessary, every 6-8 hours.

Side effects:

Allergic reactions:

urticaria, photosensitivity, skin rash, itching.

From the nervous system:

drowsiness, general weakness, a decrease in the speed of psychomotor reactions, impaired coordination and speed of reaction, a feeling of fatigue. In some cases, agitation (especially in children), insomnia, irritability, euphoria, dizziness, tremors.

From the digestive tract:

possible sensations of dry mouth, disturbance of the functions of the gastrointestinal tract (epigastric discomfort, nausea, vomiting, loss of appetite).

On the part of the cardiovascular system:

lowering blood pressure, tachycardia, extrasystole.

From the urinary system:

disorders of urination.

From the respiratory system:

dryness of the mucous membrane of the nose and throat, nasal congestion, thickening of the secretions of the bronchi, tightness in the chest and shortness of breath.

From the side of the hematopoietic organs:

hemolytic anemia, thrombocytopenia, agranulocytosis.

Overdose:

Symptoms:

oppression or excitement (especially in children) of the functions of the central nervous system, including depression, confusion; dilated pupils, dry mouth, disorders of the gastrointestinal tract.

Treatment:

there is no specific antidote. Supportive measures include blood pressure control, drugs that increase blood pressure, and intravenous plasma replacement fluids.

Interaction: It potentiates the effect of alcohol and drugs that depress the central nervous system (neuroleptics, tranquilizers, sedatives and hypnotics, anticonvulsants, anesthetics). Monoamine oxidase (MAO) inhibitors increase the anticholinergic activity of diphenhydramine. Strengthens the anticholinergic effects of drugs with m-anticholinergic activity. With a general appointment with psychostimulants, an antagonistic interaction is noted. Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Special instructions:

Cannot be administered subcutaneously due to irritant effect.

During the period of treatment, you should avoid drinking alcoholic beverages and ultraviolet radiation.

The antiemetic effect of diphenhydramine can complicate the diagnosis of appendicitis and the recognition of symptoms of overdose (it is necessary to inform the doctor about the use of this drug).

Impact on the ability to drive and operate machinery.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Impact on the ability to drive vehicles Wed and fur .:During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions. Release form / dosage:Solution for intravenous and intramuscular administration of 10 mg / ml.

It has an antihistamine, antiallergic, antiemetic, hypnotic, local anesthetic effect. Blocks histamine H 1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue edema, itching and hyperemia. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions in inflammation and allergies in comparison with systemic ones, i.e. lowering blood pressure. It causes local anesthesia (when taken orally, there is a short-term feeling of numbness of the oral mucosa), has an antispasmodic effect, blocks the cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H 3 - histamine receptors in the brain and inhibits the central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin), to a lesser extent in allergic bronchospasm. In bronchial asthma, it is inactive and is used in combination with theophylline, ephedrine and other bronchodilators.

Pharmacokinetics

When taken orally, it is rapidly and well absorbed. Binds to plasma proteins by 98-99%. The maximum concentration (C max) in plasma is achieved within 1-4 hours after ingestion. Most of the diphenhydramine taken is metabolized in the liver. The half-life (T 1/2) is 1-4 hours. It is widely distributed in the body, passes through the blood-brain barrier and the placenta. It is excreted in milk and may cause sedation in infants. During the day, it is completely excreted from the body mainly in the form of benzhydrol conjugated with glucuronic acid, and only in a small amount - unchanged. The maximum effect develops within 1 hour after oral administration, the duration of action is from 4 to 6 hours.

Indications for use

Urticaria, hay fever, vasomotor rhinitis, itchy dermatoses, acute iridocyclitis, allergic conjunctivitis, angioedema, capillary toxicosis, serum sickness, allergic complications during drug therapy, blood transfusion and blood substituting fluids; complex therapy of anaphylactic shock, radiation sickness, bronchial asthma, gastric ulcer and hyperacid gastritis; colds, sleep disorders, sedation, extensive injuries to the skin and soft tissues (burns, crush injuries); parkinsonism, chorea, motion sickness and air sickness, vomiting, Meniere's syndrome; conducting local anesthesia in patients with a history of allergic reactions to local anesthetic drugs.

Contraindications

Hypersensitivity, breastfeeding, childhood (neonatal period and prematurity), angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcers, pyloroduodenal obstruction, bladder neck stenosis, pregnancy, bronchial asthma.

Method of administration and dosage

The drug is taken orally. Adults are prescribed 30-50 mg 1-3 times a day, the course of treatment is 10-15 days. For the prevention of motion sickness when driving, you should take a single dose of 30-50 mg 30-60 minutes before the trip; for insomnia - 30-50 mg at bedtime. The maximum single dose is 100 mg, the daily dose is 250 mg. Children aged 6-12 years are prescribed 15-30 mg per dose.

Side effect

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, increased excitability (especially in children), irritability, nervousness, insomnia, euphoria, confusion , tremor, neuritis, convulsions, paresthesia; visual impairment, diplopia, acute labyrinthitis, tinnitus. In patients with local brain damage or epilepsy, it activates (even in low doses) convulsive discharges on the EEG and can provoke an epileptic seizure.

From the side of the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

From the digestive tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation.

From the genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation.

On the part of the respiratory system: dryness of the nose and throat, nasal congestion, thickening of the secretions of the bronchi, tightness in the chest and shortness of breath.

Allergic reactions: rash, urticaria, anaphylactic shock.

Others: sweating, chills, photosensitivity.

The active ingredient is Diphenhydramine.

1 ml of solution contains 10 mg of this active substance in the form of diphenhydramine hydrochloride. Injection water acts as an additional substance.

1 tablet contains 50 mg of active substance.

Release form

Tablets and solution of Diphenhydramine for intravenous and intramuscular injection.

pharmachologic effect

Diphenhydramine - what is it?

Diphenhydramine is H1-histamine receptor blocker... It has a sedative and hypnotic effect.

Pharmacological group: H1-antihistamines.

Pharmacodynamics and pharmacokinetics

The main, active substance is Diphenhydramine... The mechanism of action is based on the inhibitory effect of the drug on the central, cholinergic structures, blocking the H3-histamine receptors in the brain. Diphenhydramine relieves attacks of itching, tissue edema, hyperemia, prevents spasms of smooth muscle tissue, has a positive effect on capillary permeability... Taking oral forms causes a short-term feeling of numbness in the mouth. The drug has antiparkinsonian, hypnotic, sedative, antiemetic effects. By blocking the cholinergic receptors of the ganglia, it lowers blood pressure, can increase the existing hypotension... In persons with epilepsy and local brain damage, even low doses of Diphenhydramine can provoke epileptic seizure, and on the EEG activation of epileptic discharges is noted. The drug is most effective in bronchospasm provoked by the intake of histamine liberators (morphine, tubocurarine). The drug is least effective for bronchospasm of allergic genesis. With repeated doses, the hypnotic and sedative effects are more pronounced. The drug begins to act an hour after entering the body, effective action lasts up to 12 hours.

Indications for the use of Diphenhydramine

For what and from what are the tablets and the solution prescribed?

The drug is used to relieve allergic reactions, with itchy dermatosis, allergic dermatitis, rhinosinusitis, vasomotor rhinitis, acute iridocyclitis, allergic conjunctivitis. The drug is used for insomnia, chorea, Parkinson's disease, radiation sickness, air sickness, seasickness, Meniere's syndrome, vomiting in pregnant women. The drug is prescribed as premedication, with extensive damage to soft tissues and skin of a traumatic nature, with serum sickness, hemorrhagic vasculitis.

Contraindications

Diphenhydramine is not prescribed for prostatic hyperplasia, angle-closure glaucoma, epilepsy, bladder stenosis, stenosing peptic ulcer of the digestive system. With bronchial asthma, breastfeeding, pregnancy is prescribed with caution.

Side effects

Taking the drug may cause tremors, dizziness, numbness in the mouth, dry mouth, increased drowsiness, photosensitivity, asthenia, headaches, nausea, paresis of accommodation, decrease in the speed of psychomotor reaction, impaired coordination of movements. The use of the drug Diphenhydramine in children may be accompanied by a feeling euphoria, irritability, paradoxical insomnia.

Instructions for the use of Diphenhydramine (Way and dosage)

Diphenhydramine tablets, instructions for use

30-50 mg from one to three times a day, the duration of therapy is 10-15 days.

For insomnia, 50 mg is prescribed half an hour before bedtime.

At postencephalic, idiopathic parkinsonism initially appoint 25 mg three times a day, subsequently the dosage is gradually increased to 50 mg 4 times a day.

With motion sickness, every 6 hours you need to take 25-50 mg of tablets.

Instructions for the use of Diphenhydramine in ampoules

A solution of Diphenhydramine is injected intravenously with 20-50 mg of the drug, previously dissolved in 100 ml of 0.9 sodium chloride, intramuscular injections are injected once 10-50 mg.

Instructions for the use of rectal suppositories with diphenhydramine

Rectal suppositories after a cleansing enema are administered twice a day.

The use of drops with diphenhydramine

In ophthalmology - 2 drops of a solution (0.2-0.5%) are instilled 3 times a day into each conjunctival sac.

In allergology - 0.05 g of the drug is administered intranasally.

Diphenhydramine overdose

Taking higher doses causes depression of the nervous system, paresis of the digestive system, dry mouth, dilated pupils, depression. No specific antidote has been developed, intravenous administration is required plasma-replacing fluids, the use of drugs that increase blood pressure. It is unacceptable to use analeptics, epinephrine.

Death, injury, heart attacks, paralysis are possible in case of severe overdose.

Interaction

Diphenhydramine enhances the effect of drugs that depress the nervous system. When used together with psychostimulants an antagonistic effect is recorded. MAO inhibitors increase the anticholinergic activity of the drug. In the treatment of poisoning, intoxication, the medicine reduces the effectiveness apomorphine.

Terms of sale

With or without a prescription? A prescription is required to purchase.

Storage conditions

Store in a dark place, out of the reach of children, at a temperature not exceeding 30 degrees Celsius.

Storage period

No more than 4 years.

special instructions

The medication negatively affects the performance of activities that require increased concentration of attention, the control of complex mechanisms, and driving. During the period of therapy, it is necessary to avoid drinking alcoholic beverages, to limit exposure to the sun and ultraviolet radiation to a minimum. The antiemetic effect of the drug can mislead the doctor in differential diagnosis. acute appendicitis, recognition of symptoms of overdose, intoxication.

International name (INN) of Diphenhydramine: Diphenhydramine.

The Pharmacopoeia contains a description under FS 42-0232-07.

It is described on Wikipedia under the name Diphenhydramine.

It is often required to know the name of the drug in Latin. For example, here's a recipe in Latin:

Rp .: Dimedroli 0.05

D. t. d. No. 10 in tabul. S.

Diphenhydramine sticks in Latin: baculi cum dimedrolum.

Active ingredient structural formula:

Is diphenhydramine a drug?

In fact, the medication is not a drug, however, in combination with alcoholic beverages and in large doses, it causes hallucinations, as well as addiction with frequent use.

Can I drink Diphenhydramine in ampoules?

In general, it is possible, however, the concentration of the active substance in ampoules is less than in tablets.

Diphenhydramine and alcohol

It is contraindicated to take the drug with alcohol. The effect of alcohol increases, the hypnotic effect increases, and severe damage to the body is possible. It is impossible to predict the outcome, especially with the use of large doses. Vodka with diphenhydramine can be the last drink in the life of a person who has consumed this mixture, lethal dose can be quite small when combined with alcohol.

During pregnancy

Contraindicated in pregnancy and breastfeeding.

Analogs Matching ATX level 4 code:

The analogs are the means Kalmaben, Dramina.

Reviews of Diphenhydramine

The drug works quickly and helps with fever, insomnia, pain, allergies. The disadvantages are side effects medication, as well as the fact that it is considered obsolete.

Diphenhydramine price where to buy

The price of Diphenhydramine in tablets is 3-6 rubles for a pack of 10 pieces. How much do pills cost in Ukraine? Packaging can be purchased for 6-8 hryvnia.

You can buy Diphenhydramine in ampoules at a price of 25-30 rubles for 10 pieces in Russia and for 15-18 UAH in Ukraine.

• Online pharmacies in Russia
• Online pharmacies of Ukraine
• Online pharmacies of KazakhstanKazakhstan

Zdravzona

Diphenhydramine 50mg No. 20 tablets Dalkhimpharm OJSC

Diphenhydramine vial 1% 1ml No. 10 amp.

Diphenhydramine 50mg No. 10 tablets Barnaul Medicines Plant LLC

Diphenhydramine 1% 1ml No. 10 amp. Belmedpreparaty

Diphenhydramine 1% 1ml ampoule No. 10

Pharmacy IFK

Diphenhydramine Belmedpreparaty (Minsk), Belarus

Dimedrol Dalkhimpharm (Khabarovsk), Russia

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Pharmacy24

DimedrolHealth to the people (Ukraine, Kharkiv)

Diphenhydramine Galichpharm (Ukraine, Lviv)

Dimedrol Darnitsa (Ukraine, Kiev)

PaniApteka

Diphenhydramine solution for injections 1% amp. 1ml No. 10 Darnitsa

Diphenhydramine solution for injections 1% amp. 1ml No. 10 Darnitsa

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BIOSPHERE

Diphenhydramine 50 mg No. 10 tab.

Diphenhydramine 1% / 1 ml No. 10 solution for injection amp.

Diphenhydramine 50 mg No. 10 tab.

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NOTE! Information about medications on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Diphenhydramine, be sure to consult with your doctor.

General characteristics of the tool

A remedy such as "Diphenhydramine" in ampoules is an active antihistamine of synthetic origin, which has a pronounced antiallergic effect. The use of this medication has a characteristic hypnotic and sedative effect on the human body, similar to the effect that occurs as a result of taking antipsychotics. In addition, the drug "Diphenhydramine" (in ampoules) has antispasmodic, anti-inflammatory, central anticholinergic, local anesthetic, antiemetic and ganglion-blocking effects. It effectively relaxes the spasms of the so-called smooth muscles, reduces the permeability of thin blood vessels and tissue edema, prevents the development of such an allergic condition as anaphylactic shock.

Description of the pharmacological action

At the heart of pharmacological action This antihistamine has an effect directly on the central nervous system of a person due to the blockade of H3-histamine receptors in the brain and the subsequent inhibition of cholinergic structures. It should be especially noted that this antispasmodic and local anesthetic drug in people with epilepsy is able to activate epileptic discharges on the electroencephalogram and even provoke the onset of an epileptic seizure. In turn, antagonism with histamine is more pronounced in relation to various local vascular reactions in allergy and inflammation than to systemic ones.

Features of the pharmacokinetics of the drug

As for the pharmacokinetics of such an antihistamine as "Diphenhydramine" in ampoules, it is absorbed from the gastrointestinal tract in a relatively short time, reaching the highest concentration twenty to forty minutes after administration. The bioavailability of this ganglion blocking drug is about 50%. Maximum drug concentrations are usually determined in the kidneys, lungs, liver, spleen, muscles, and brain. The half-life of the drug from the body is four to ten hours.

Scope of use of the antihistamine

The instruction recommends to use the drug "Diphenhydramine" (in ampoules) during the treatment of vasomotor rhinitis, acute forms of iridocyclitis, hay fever, urticaria and allergic conjunctivitis. In addition, this antihistamine and anti-inflammatory agent is indicated for use in pruritic dermatoses, capillarotoxicosis, serum sickness and angioedema. After transfusion of blood and various fluids replacing it, it is similarly recommended to use the ganglion-blocking drug "Diphenhydramine".

Injections with this medicine are also prescribed in case of the development of allergic complications after a particular drug therapy. In addition, this antihistamine very well helps with anaphylactic shock, radiation sickness, stomach ulcers, bronchial asthma, premedication, parkinsonism, sleep disorders, hyperacid gastritis, colds, chorea, Meniere's syndrome, extensive injuries of the skin and soft tissues, sea or air illness. Finally, quite often this local anesthetic drug is used during local anesthesia in patients who have previously experienced allergic reactions to other local anesthetic drugs.

List of the most common contraindications

It is categorically not recommended to use the antihistamine and antispasmodic agent "Diphenhydramine" (in ampoules) if a person has prostate hypertrophy, angle-closure glaucoma, pyloroduodenal obstruction or bladder neck stenosis. In addition, contraindications are stenosing gastric ulcer and bronchial asthma. It is also not worth using this ganglion-blocking and anti-inflammatory drug while carrying a child and while breastfeeding a newborn baby. The list of direct contraindications includes increased individual sensitivity of the body.

Find out all about Diphenhydramine, is Diphenhydramine possible for children. Advice and opinions of nutritionists.

Answer:

Can Diphenhydramine be given to children? Today, most pediatricians are urging to completely abandon the use of this drug. Recent studies have shown that it generates a lot side effects, therefore, to treat babies, you need to use more harmless medicines.

In pediatric practice, Diphenhydramine is often used as part of a lytic consistency with a significant and prolonged increase in body temperature, according to the doctor's prescription, in compliance with the dose.

Many mothers are interested in the question, is it possible for children to have Diphenhydramine with Analgin? The huge number of side effects that harm the body have led to a decrease in the number of cases of its use in pediatric practice.

The use of Diphenhydramine for a long period, especially when the dose is exceeded, can cause children to lag behind in intellectual and physiological formation.

With a rapid increase in body temperature, Analgin with Diphenhydramine helps very quickly. The fever subsides within 15 minutes after the injection.

Also, many are interested in the question, is it possible to drink Diphenhydramine in ampoules? Doctors believe that injectables do not work when taken orally.

Diphenhydramine in ampoules is a sedative, hypnotic and antihistamine drug, which is characterized by weak ganglion blocking and local anesthetic properties.

Compound

The components that make up diphenhydramine in ampoules are as follows:

• diphenhydramine hydrochloride acts as the main component;
• in the role of an auxiliary - water for injection.

Indications for use

Diphenhydramine is prescribed by a doctor in case of:

1. allergic reactions (urticaria, hay fever);
2. allergic conjunctivitis;
3. acute iridocyclitis;
4. vasomotor rhinitis;
5. allergic dermatitis;
6. itchy dermatosis;
7. parkinsonism, chorea, insomnia;
8. sea ​​and air sickness, radiation sickness.

Contraindications for use

Instructions for the use of diphenhydramine in ampoules suggests the following contraindications to the use of the drug:

1. hypersensitivity;
2. at the time of lactation;
3. angle-closure glaucoma;
4. hypertrophy of the prostate;
5. bladder neck stenosis;
6. bronchial asthma;
7. pregnancy.

Method of use, dosage and side effects

Instructions for the use of diphenhydramine assumes the introduction of the drug intramuscularly. Adults and children over 12 years old can use diphenhydramine in an amount of 10-50 mg.

If at least one of the symptoms listed below occurs, you should immediately come for a consultation with a specialist.

When using diphenhydramine, the patient may experience the following side effects:

1. digestive system: dry mouth, nausea, vomiting, constipation and diarrhea;
2. nervous system: headache, drowsiness, dizziness, weakness, nervousness, anxiety, irritability, insomnia, neuritis, convulsions;
3. sensory organs: tinnitus, changes in vision, acute labyrinthitis;
4. genitourinary system: difficult and frequent urination, early menstruation, urinary retention.

In case of an overdose, patients experience suppression of the central nervous system, accompanied by excitement or depression, dry mouth, paresis of the digestive tract.

Interaction of diphenhydramine with other drugs

1. It enhances the action of ethanol and drugs that depress the central nervous system.
2. When combined with psychostimulants, an antagonistic interaction is observed.
3. The effectiveness of apomorphine in the treatment of poisoning decreases.
4. The anticholinergic effects of the drug with M-anticholinergic activity are enhanced.

The instructions for use assume that diphenhydramine is pharmaceutically incompatible with amphotericin B, cefmetazol sodium, cephalothin sodium, hydrocortisone succinate, barbiturates, and some radio-opaque agents.

Precautionary measures

1. During pregnancy, diphenhydramine should be used under the strict supervision of a physician. When diphenhydramine is prescribed during pregnancy, a newborn may experience diarrhea and tremors during the first 5 days after birth. During the period of using diphenhydramine, you must stop breastfeeding.
2. The use of diphenhydramine in pediatrics. Diphenhydramine should not be administered to newborn premature babies. In children, when using antihistamines in case of overdose, hallucinations, convulsions and death can occur. In both adults and children, taking antihistamines can reduce mental alertness. In young children, diphenhydramine promotes arousal.
3. When using antihistamines in old age, you may experience: dizziness, sedation and hypotension.
4. Diphenhydramine has a similar effect on atropine, so it should be used with extreme caution in patients with bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension.
5. Diphenhydramine can cause drowsiness, so you should not drink alcohol while using diphenhydramine, as it has an additive effect.
6. When using diphenhydramine, it is necessary to take into account its effect on the ability to drive vehicles, therefore, patients need to abandon all types of activities for which increased attention is needed.