Recently, the drug Lyrica is becoming more widespread. This drug is available over the counter at almost any pharmacy and is a remedy for neuropathic pain.

As a good pain reliever, Lyrica became popular in narcology, and then, from the sphere of doctors, it went out into the streets - to drug addicts.

So what is Lyrica? What harm and consequences is the use of this so-called "pharmacy" drug? So...

Lyrics: a drug that has nothing lyrical about it.

Drug addiction is a terrible and destructive disease that is constantly taking on new forms. And every time drug addicts find new ways of stupefying. Increasingly, so-called “pharmacy drugs” are used to obtain a narcotic "high". These are drugs, the use of which was originally intended for completely different purposes than for obtaining narcotic intoxication. Not so long ago, a drug called "Lyrica" ​​was widely used in the drug addict environment.

Video: "Lyrical" mood is available to everyone

The lyric drug is nothing more than a medicine used to combat pain and cramps. To be precise, Pregabalin, aka Lyrica, is an antiepileptic drug. It is a strong pain reliever.

Lyrics is used in narcology to relieve withdrawal symptoms during withdrawal symptoms and is an auxiliary component in the treatment program. However, relieving withdrawal symptoms, the use of Lyrica, even in medicinal doses, leads to addiction.

Like any drug, Lyrica is addictive.

The drug Lyrica became widespread due to the fact that the drug can be purchased in many pharmacies without a prescription. And this is despite the fact that since June 1, 2012, a law was passed, and the over-the-counter dispensing of the drug was prohibited. However, unscrupulous sellers, in pursuit of easy drug money, turn a blind eye to this ban, in some cases selling death even "under the roof" of law enforcement agencies.

Despite the fact that Lyrica is not an opioid, its use causes about the same sensations as heroin. A state of serenity, calmness, relaxation and well-being arises.

Recently, "lyric" addicts have been practicing a combination of Alcohol + pill and Lyrica. Ethyl alcohol increases drug intoxication, while causing multiple damage to the health of the addict.

Signs of using Lyrica:

• Unsteady, staggering gait. It is difficult for an addict to stay on his feet.
• Increased sweating.
• Excitability.
• Aggression.
• Unreasonable frequent mood swings.
• Dilated pupils.

Consequences of using Lyrics:

• The main and main consequence of the use of Lyrics is development of persistent drug addiction.
• Drowsiness.
• Confused consciousness.
• Headache.
• Decreased sex drive / libido.
• Tremor.
• Memory impairment.
• Impaired concentration.
• Depression.
• Violation of speech.
• Stupor.
• Psychomotor agitation.
• Myoclonic convulsions and syncope.
• Coma.
• Death.

Due to the low knowledge of the consequences of using Lyric tablets for narcotic purposes, it can be assumed that this is not a complete list of the consequences and "side effects" of the drug.

Lyrica's analogs

Drugs such as:

• Pregabalin Richter
• Pregabalin Conan
• Algerica

They are analogs of the drug with the trade name "Lyrica", and the active substance contained in them is identical. It is called pregabalin, the chemical formula is (S) -3- (aminomethyl) -5-methylhexanoic acid or (C8H17NO2).

There were cases when a drug addict asked relatives or friends to bring one of the listed analogs of the lyrics, while undergoing treatment. Therefore, it must be remembered that these are all different commercial names of the same drug.

How to quit using Lyrica?

For many addicts, the excruciating symptoms of Lyrica withdrawal lead to relapses. If you have repeatedly tried to "get off" from Lyrica, but fell off and rolled back into the pit of this pernicious addiction, if you are unable to quit on your own - do not hesitate and postpone! Be sure to see a doctor! Whether it is a specialized private clinic or a state narcological dispensary.

Usually, in clinics, treatment is carried out in two stages:

The first step is detoxification. Medical detoxification measures cleanse the drug from the body and effectively help relieve withdrawal symptoms.

This is followed by rehabilitation treatment aimed at eliminating the psychological dependence on this drug and at the formation of the patient's principles of a healthy lifestyle. Such treatment helps to permanently get rid of the desire to return to drug use.

Video: drug lyrics

Lyrica (pregabalin): mechanism of action

Drug addiction is becoming one of the most important problems in modern society. To obtain vivid sensations, many medications intended for other purposes began to be used. "Pharmacy" drugs are more affordable than real ones, and people naively consider them less harmful.

Lyrica has become widespread as a "euphoric" means, causing sensations similar to the effect of heroin. But, like him, pregabalin very quickly causes a severe addiction, which only a few can cope with without inpatient treatment in specialized clinics.

What is "Lyrics"

It is a pharmaceutical preparation with the active ingredient pregabalin. Used to relieve pain and cramps. Available in capsules in blisters with a dosage of 25, 50, 75, 100, 150, 200 or 300 mg. The manufacturer of this drug is Pfizer, Germany.

Medical Uses of Pregabalin

Indications for the use of Lyrica:

In drug addiction practice, pregabalin is used to relieve withdrawal withdrawal symptoms by relieving anxiety, reducing physical pain, relieving spasms, and relieving the feeling of muscle and joint twisting.

Lyrics are an aid in the fight against drug addiction. By alleviating withdrawal symptoms, taking pregabalin even at therapeutic dosages increases the risk of addiction.

Narcological effect

The side effects of the drug Lyrica, if used incorrectly, if the therapeutic dosage is exceeded, cause sensations similar to those created by heroin. This is due to its effect on opioid receptors.

The narcotic effect of taking Lyrica:

• a state of bliss, joy, elation;
• increased libido;
• lightness in the body;
• complete pacification;
• a sense of well-being;
• relaxation.

To achieve a vivid effect, to enhance the effect of Lyrica, drug addicts mix pregabalin with alcohol.

Signs of using Lyrics

When taking a narcotic drug, various symptoms may appear. The presence of several of the following are good reasons to closely observe a person.

The main signs of using pregabalin:

Side effects

The number and severity of side effects from taking pregabalin increases with dosage and frequency of administration.

Side effects:

Overdose

An overdose of pregabalin is dangerous to humans and can lead to many serious problems.

Most of the symptoms of an overdose are identical to many of the side effects of this drug.

Overdose symptoms include:

• dizziness;
• constriction of the pupils;
• swelling in the legs;
• breathing disorder;
• muscle spasms;
• drowsiness;
• confusion of consciousness;
• anxiety;
• to whom;
• death.

When such signs appear, it is necessary to stop taking the medication, rinse the stomach. In case of significant intoxication, you should contact a medical institution for detoxification.

Negative consequences of use

Long-term use of pregabalin or exceeding the therapeutic dose can cause many negative consequences.

The main ones are:

Drug dependence

Addiction to Lyrica can occur even in a healthy person without bad habits if the dosage is exceeded or if the drug is particularly susceptible.

A person who is prone to the emergence of addictions or is already sick with drug addiction quickly develops a persistent and strong attachment to this drug due to its chemical and psychoactive effect.

With a regular and sufficiently long period of taking Lyrica, the resulting dependence is so strong that refusal from it leads to the emergence of a strong withdrawal syndrome.

How to remove Lyrica from the body

To remove pregabalin from the body, first of all, you must completely stop taking the drug.

The next and most important stage is detoxification, i.e. cleansing the body of toxins and pathogenic substances. The most effective will be a detoxification procedure carried out in a specialized institution.

If it is impossible to contact specialists, it is possible to speed up the process of removing Lyric from the body at home. Self-cleansing of the body must be carried out for at least 5-7 days, relief will become noticeable for 3-4 days.

Main steps:

How to quit using

It is quite difficult to stop taking Lyrica even with the help of specialists.

The shorter the period of using the drug, the easier it is to part with the harmful addiction. The effectiveness of refusal from Lyrica also depends on whether other drugs are taken in parallel. If the reception of Lyrica was caused by an attempt to abandon another drug by substitution, then the help of specialists will be required.

Withdrawal symptoms:

• trembling all over the body;
• insomnia;
• severe headaches;
• violation of coordination of movement;
• inability to concentrate;
• depression with mood lability;
• outbursts of aggression;
• severe cramps;
• severe muscle and joint pain;
• convulsions;
• fainting;
• coma.

Help at home

It is possible to independently fight a recently formed addiction or if a person has a very strong will and motivation to stop taking the drug.

The main help when "tying" with Lyrica will be moral support of loved ones, belief in a person's ability to part with a harmful craving, withdrawal of the drug from the body through diet, physical activity, taking certain medications, good sleep and rest.

Pain relievers and antidepressants will be required to reduce withdrawal symptoms.

With a severe withdrawal syndrome and severe withdrawal symptoms, it is necessary to contact specialized medical institutions for therapy.

Solving the problem together with a specialist

The most effective parting with dependence on Lyrica will be treatment in specialized institutions, with strong dependence and long experience, a hospital stay will be required.

Examination and consultation with a psychiatrist will reveal the degree of the disease and the state of the body.

Explanation of the course of subsequent treatment and motivation of the drug addict are necessary for a conscious decision to be cured, which is necessary when contacting a medical institution, since the patient will need to sign documents, including about possible complications during and after therapy.

A prerequisite for parting with painful cravings is a thorough detoxification for maximum cleansing of the body from the drug, restoration of self-purification functions in the body.

The next stage is rehabilitation, during which motivation for a healthy lifestyle, mental recovery and healing of diseases caused by the use of Lyrica will be formed. Also, measures will be taken to reduce the importance of the drug in a person's life and prevent breakdowns.

Similar drugs

In the preparation with the trade name "Lyrica" ​​the main active ingredient is pregabalin. There are other medicines with a similar composition.

Preparations based on the same active substance:

Lyrics, in spite of the fact that it is a medicine, very quickly causes a strong addiction. The narcotic effect of taking it occurs due to the occurrence of side effects, but in addition to pleasant effects, it is accompanied by a mass of negative ones. Regular intake of pregabalin contributes to many negative effects, often leading to death.

Lyrics - an updated description of the drug, you can read the pharmacological action, indications for use, Lyrics. Useful reviews about Lyrica -

Antiepileptic drug.
Drug: LYRICA®
The active substance of the drug: pregabalin
ATX encoding: N03AX16
KFG: Anticonvulsant drug
Registration number: ЛС-001752
Date of registration: 07.07.06
Owner reg. ID: PFIZER GmbH (Germany)

Release form Lyrica, drug packaging and composition.

Capsules with a white body and a white cap, the dosage and product code "PGN 25" are indicated on the body in black ink, the cap is marked with the inscription "Pfizer".

1 caps.
pregabalin
25 mg

Capsules with a white (with a black stripe) body and a white cap, the dosage and product code "PGN 50" are indicated on the body in black ink, the cap is marked "Pfizer".

1 caps.
pregabalin
50 mg

Excipients: lactose monohydrate, corn starch, talc.

The composition of the capsule shell: gelatin, water, titanium dioxide (E171), sodium lauryl sulfate, colloidal silicon dioxide.

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

Capsules with a white body and an orange cap, the dosage and product code “PGN 75” are indicated on the body in black ink, the cap is marked “Pfizer”.

1 caps.
pregabalin
75 mg

Excipients: lactose monohydrate, corn starch, talc.

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

Capsules with an orange body and an orange cap, the dosage and product code “PGN 100” are indicated on the body in black ink, and the caption “Pfizer” is written on the cap.

1 caps.
pregabalin
100 mg

Excipients: lactose monohydrate, corn starch, talc.

The composition of the capsule shell: gelatin, water, titanium dioxide (E171), sodium lauryl sulfate, colloidal silicon dioxide, iron oxide red (E172).

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

Capsules with a white body and a white cap, the dosage and product code "PGN 150" are indicated on the body in black ink, and the caption "Pfizer" is written on the cap.

1 caps.
pregabalin
150 mg

Excipients: lactose monohydrate, corn starch, talc.

The composition of the capsule shell: gelatin, water, titanium dioxide (E171), sodium lauryl sulfate, colloidal silicon dioxide.

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

Capsules with a light orange body and a light orange cap, the dosage and product code “PGN 200” are indicated on the body in black ink, and the caption “Pfizer” is written on the cap.

1 caps.
pregabalin
200 mg

Excipients: lactose monohydrate, corn starch, talc.

The composition of the capsule shell: gelatin, water, titanium dioxide (E171), sodium lauryl sulfate, colloidal silicon dioxide, iron oxide red (E172).

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

Capsules with a white body and an orange cap, the dosage and product code “PGN 300” are indicated on the body in black ink, and the caption “Pfizer” is written on the cap.

1 caps.
pregabalin
300 mg

Excipients: lactose monohydrate, corn starch, talc.

The composition of the capsule shell: gelatin, water, titanium dioxide (E171), sodium lauryl sulfate, colloidal silicon dioxide, iron oxide red (E172).

10 pieces. - blisters (10) - cardboard packs.
14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (4) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.

The description of the product is based on the officially approved instructions for use.

Pharmacological action Lyrica

An antiepileptic drug, the active ingredient of which is an analogue of gamma-aminobutyric acid (GABA).

Although the exact mechanism of action of pregabalin is still unclear, it has been found that pregabalin binds to an additional subunit (2-delta protein) of voltage-dependent calcium channels in the central nervous system, it is assumed that such binding may contribute to the manifestation of its analgesic and anticonvulsant effects.

Neuropathic pain

The effectiveness of pregabalin has been noted in patients with diabetic neuropathy and postherpetic neuralgia. Efficacy for other types of neuropathic pain has not been studied.

It was found that when pregabalin is taken in courses up to 13 weeks, 2 times / essence and up to 8 weeks, 3 times / day, in general, the risk of side effects and the effectiveness of the drug when taken 2 or 3 times / day are the same.

When taken in a course of up to 13 weeks, the pain decreased during the first week, and the effect persisted until the end of treatment.

There was a 50% decrease in the pain index in 35% of patients receiving pregabalin and 18% of patients taking placebo. Among patients who did not experience drowsiness, the effect of such pain relief was observed in 33% of patients in the pregabalin group and 18% of patients in the placebo group. In patients experiencing drowsiness, response rates were 48% in the pregabalin group and 16% in the placebo group.

Epilepsy

When taking the drug for 12 weeks, 2 or 3 times / day, the noted risk of side effects and the effectiveness of the drug with these dosage regimens are the same. The decrease in seizure frequency began within the first week.

Pharmacokinetics of the drug.

Pharmacokinetics of the drug.

pregabalin in the range of recommended daily doses is linear, interindividual variability is low (<20%). Фармакокинетику препарата при повторном применении можно предсказать на основании данных приема единичной дозы. Следовательно, необходимости в регулярном мониторировании концентрации прегабалина нет.

Suction

Pregabalin is rapidly absorbed after oral administration on an empty stomach. Cmax in plasma is achieved after 1 hour with both single and repeated use. The oral bioavailability of pregabalin is 90% and does not depend on the dose. With repeated use, the equilibrium state is achieved after 24-48 hours. The absorption of pregabalin is impaired by the influence of food. In this case, Cmax decreases by about 25-30%, and the time to reach Cmax increases to about 2.5 hours. However, food intake does not have a clinically significant effect on the total absorption of pregabalin.

Distribution

The Vd of pregabalin after oral administration is approximately 0.56 L / kg. The drug does not bind to plasma proteins.

Metabolism

Pregabalin is practically not metabolized. After taking labeled pregabalin, approximately 98% of the radioactive label was detected in the urine unchanged. The proportion of N-methylated derivative of pregabalin, which is the main metabolite found in urine, was 0.9% of the dose. There were no signs of racemization of the S-enantiomer of pregabalin to the R-enantiomer.

Withdrawal

Pregabalin is excreted mainly by the kidneys unchanged. The average T1 / 2 is 6.3 hours. The clearance of pregabalin from plasma and renal clearance are directly proportional to creatinine clearance.

Pharmacokinetics of the drug.

in special clinical cases

Patient gender has no clinically significant effect on plasma pregabalin concentration.

In case of impaired renal function, it should be borne in mind that the clearance of pregabalin is directly proportional to the clearance of creatinine. Due to the fact that the drug is mainly excreted by the kidneys, in case of impaired renal function, it is recommended to reduce the dose of pregabalin. In addition, pregabalin is effectively removed from plasma during hemodialysis (after a 4-hour hemodialysis session, plasma concentrations of pregabalin decrease by about 50%), after hemodialysis, an additional dose of the drug must be prescribed.

Pharmacokinetics of the drug.

pregabalin has not been specifically studied in patients with hepatic dysfunction. Pregabalin practically does not undergo metabolism and is excreted mainly unchanged in the urine, therefore, impaired liver function should not significantly change the concentration of the drug in plasma.

When prescribing the drug to elderly patients (over 65 years old), it should be borne in mind that the clearance of pregabalin tends to decrease with age, which reflects an age-related decrease in CC. Elderly people with impaired renal function may need to reduce the dose of the drug.

Indications for use:

Neuropathic pain:

Treatment of neuropathic pain in adults.

Epilepsy:

As an adjuvant in adults with partial seizures, with or without secondary generalization.

Dosage and method of administration of the drug.

The drug should be taken orally, regardless of food intake, in a daily dose of 150 to 600 mg in 2 or 3 divided doses.

Treatment of neuropathic pain begins with a dose of 150 mg / day. Depending on the achieved effect and tolerance, after 3-7 days, the dose can be increased to 300 mg / day, and, if necessary, after another 7 days, up to a maximum dose of 600 mg / day.

For epilepsy, treatment begins with a dose of 150 mg / day. Taking into account the achieved effect and tolerance, after 1 week the dose can be increased to 300 mg / day, and after another week - to a maximum dose of 600 mg / day.

If treatment with Lyrica in patients with neuropathic pain or epilepsy needs to be discontinued, it is recommended to do so gradually over a period of at least 1 week.

For patients with impaired renal function, the dose is selected individually, taking into account the CC (Table 1), which is calculated according to the following formula:

For men weighing> 60 kg:

(body weight in kg) x (140 - age in years)

QC (ml / min) = ————————————————————————

72 x serum creatinine (mg / dl)

For women:

CC (ml / min) = CC value for men x 0.85

In patients receiving hemodialysis treatment, the daily dose of pregabalin is adjusted according to renal function. An additional dose is prescribed immediately after each 4-hour hemodialysis session (Table 1).

Table 1. Adjustment of the dose of pregabalin taking into account renal function
Creatinine clearance (ml / min)
Daily dose of pregabalin
Frequency rate of admission per day
Starting dose (mg / day)
Maximum dose (mg / day)
60
150
600
2-3
30 — <60
75
300
2-3
15 — <30
25-50
150
1-2
<15
25
75
1
Additional dose after dialysis

25mg
100mg
Once

In patients with impaired liver function, dose adjustment is not required.

Elderly patients (over 65 years of age) may need to reduce the dose of pregabalin due to decreased renal function.

Side effects of Lyric:

Dizziness and drowsiness were the most common adverse events reported in clinical experience with pregabalin in over 9,000 patients. The observed events were usually mild to moderate. Withdrawal rates for pregabalin and placebo due to adverse reactions were 13% and 7%, respectively. The main adverse events requiring discontinuation of treatment were dizziness and drowsiness.

The table lists all adverse events that were higher than those in the placebo group (observed in more than 1 person). They are distributed over systems and frequency (very frequent -> 1/10, frequent -> 1/100,<1/10, нечастые — >1/1000, <1/100) и редкие — <1/1000.

The listed adverse events could be associated with the underlying disease and / or concomitant therapy.

From the hematopoietic system: rare - neutropenia.

From the side of metabolism: frequent - increased appetite; infrequent - anorexia; rare - hypoglycemia.

From the side of the psyche: frequent - euphoria, confusion, decreased libido, irritability; infrequent - depersonalization, anorgasmia, anxiety, depression, agitation, mood lability, increased insomnia, depressed mood, difficulty in finding words, hallucinations, unusual dreams, increased libido, panic attacks, apathy; rare - disinhibition, high spirits.

From the side of the central nervous system and peripheral nervous system: very frequent - dizziness, drowsiness; frequent - ataxia, impaired attention, impaired coordination, memory impairment, tremor, dysarthria, paresthesia; infrequent - cognitive disorders, hypesthesia, visual field defects, nystagmus, speech impairment, myoclonic seizures, weakening of reflexes, dyskinesia, psychomotor hyperactivity, dizziness in an upright position, hyperesthesia, loss of taste, burning sensation on mucous membranes and skin, intentional tremor, stupor fainting; rare - hypokinesis, parosmia, writer's spasm.

From the side of the organ of vision: frequent - fog before the eyes, diplopia; infrequent - decreased visual acuity, eye pain, asthenopia, as well as dry eyes, puffiness of the eyes, increased lacrimation; rare - flickering sparks in front of the eyes, eye irritation, mydriasis, oscillopsia (subjective sensation of vibrations of the objects in question), impaired perception of depth of vision, loss of peripheral vision, strabismus, increased brightness of visual perception.

On the part of the organ of hearing and vestibular apparatus: frequent - dizziness; rare - hyperacusis.

From the side of the heart: infrequent - tachycardia; rare - AV block I degree, sinus tachycardia, sinus arrhythmias, sinus bradycardia.

From the side of the vessels: infrequent - hot flashes; rare - a decrease in blood pressure, cooling of the extremities, an increase in blood pressure.

From the respiratory system: infrequent - shortness of breath, dryness of the nasal mucosa; rare - nasopharyngitis, cough, nasal congestion, nosebleeds, rhinitis, snoring, tightness in the throat.

From the digestive system: frequent - dry mouth, constipation, vomiting, flatulence; infrequent - increased salivation, gastroesophageal reflux, sensation of decreased sensitivity in the oral cavity; rare - ascites, dysphagia, pancreatitis.

Dermatological reactions: infrequent - sweating, papular rash; rare - cold sweat, urticaria.

From the musculoskeletal system: infrequent - muscle twitching, joint swelling, muscle cramps, myalgia, arthralgia, back pain, limb pain, muscle stiffness; rare - spasm of the cervical muscles, neck pain, rhabdomyolysis.

From the urinary system: infrequent - dysuria, urinary incontinence; rare - oliguria, renal failure.

Reproductive system disorders: frequent - erectile dysfunction; infrequent - delayed ejaculation, sexual dysfunction; rare - amenorrhea, breast pain, discharge from the mammary glands, dysmenorrhea, breast hypertrophy.

On the part of the body as a whole: frequent - fatigue, peripheral edema and generalized edema, a feeling of intoxication, gait disturbance; infrequent - asthenia, falls, thirst, chest tightness; rare - increased pain with anasarca, fever, chills.

On the part of laboratory indicators: frequent - an increase in body weight; infrequent - an increase in the activity of ALT, CPK, AST, a decrease in the number of platelets; rare - an increase in blood glucose, creatinine, a decrease in blood potassium levels, a decrease in body weight, a decrease in the number of leukocytes in the blood.

The following side effects have been reported with post-marketing surveillance.

From the side of the central nervous system: headache.

From the digestive system: rarely - swelling of the tongue, nausea.

Others: rarely - facial edema.

Contraindications to the drug:

Children and adolescents up to 17 years old inclusive (no data on use);

Hypersensitivity to the active substance or any other component of the drug.

With caution, the drug should be prescribed for renal failure, in the presence of rare hereditary diseases.

Application during pregnancy and lactation.

There are no adequate data on the use of pregabalin during pregnancy.

In experimental studies on animals, the drug had a toxic effect on reproductive function.

In this regard, the drug Lyrica can be prescribed during pregnancy only if the intended benefit to the mother clearly outweighs the possible risk to the fetus.

When using the drug Lyrica, women of reproductive age should use adequate methods of contraception.

There is no information on the elimination of pregabalin in breast milk in women.

However, in experimental studies it was found that it is excreted in breast milk in rats.

In this regard, it is recommended to stop breastfeeding during treatment with Lyrica.

Special instructions for the use of Lyrics.

The drug should not be administered to patients with rare hereditary diseases, including galactose intolerance, Lapp lactase deficiency and impaired glucose / galactose absorption.

In some patients with diabetes mellitus, in case of weight gain during treatment with Lyrica, it may be necessary to adjust the doses of hypoglycemic drugs.

Treatment with Lyrica was associated with dizziness and drowsiness, which increase the risk of accidental injury (falls) in the elderly. Until patients assess the possible effects of the drug, they should be careful.

Information about the possibility of canceling other anticonvulsants in the suppression of seizures with pregabalin and the advisability of monotherapy with this drug is insufficient.

Use in pediatrics

The safety and efficacy of the drug in children under 12 years of age and adolescents aged 12-17 years have not been established.

Influence on the ability to drive vehicles and control mechanisms

Lyrica drug can cause dizziness and drowsiness and, accordingly, affect the ability to drive and use complex equipment. Patients should not drive a car, use sophisticated equipment or perform other potentially hazardous activities until the individual patient's response to taking the drug has been determined.

Drug overdose:

In case of an overdose of the drug (up to 15 g), no adverse reactions not described above were recorded.

Treatment: gastric lavage, supportive therapy and, if necessary, hemodialysis are performed.

Interaction of Lyric with other drugs.

Pregabalin is excreted in the urine mainly unchanged, undergoes minimal metabolism in humans (less than 2% of the dose is excreted in the form of metabolites in the urine), does not inhibit the metabolism of other drugs in vitro and does not bind to plasma proteins, therefore it is unlikely to be able to enter into pharmacokinetic interaction.

There was no evidence of a clinically significant pharmacokinetic interaction of pregabalin with phenytoin, carbamazepine, valproic acid, lamotrigine, gabapentin, lorazepam, oxycodone, or ethanol. It was found that oral hypoglycemic drugs, diuretics, insulin, phenobarbital, tiagabine and topiramate do not have a clinically significant effect on pregabalin clearance.

When using oral contraceptives containing norethisterone and / or ethinyl estradiol, simultaneously with pregabalin, the equilibrium

Pharmacokinetics of the drug.

both drugs did not change.

Repeated oral administration of pregabalin with oxycodone, lorazepam, or ethanol did not have a clinically significant effect on respiration. Pregabalin appears to enhance the cognitive and motor impairment caused by oxycodone. Pregabalin may potentiate the effects of ethanol and lorazepam.

Conditions of sale in pharmacies.

The drug is available with a prescription.

Terms of storage conditions of the drug Lyrica.

The drug should be stored in a dry place out of the reach of children at a temperature not exceeding 25 ° C. Shelf life is 3 years. Do not take the drug after the expiration date.

Initially, the lyric's drug was not such. Almost all drugs that are prohibited for use today were developed as medicines for the good, which were first used to relieve pain of varying severity. The same fate befell the lyrics.

Modern narcology initially used lyrics only as an aid in the treatment of other types of drug addiction. The tool was aimed at reducing the manifestations of withdrawal. Doctors confirm this theory, saying that the drug is indeed capable of somewhat improving the condition of the addict. The symptoms of his addiction are greatly dulled.

After the dissemination of such information to the masses, drug addicts took note of it and are now using it as a full-fledged means giving a new feeling of euphoria. So the lyrics from a useful medication turned into a dangerous remedy. Although the drug is not an opioid drug, it carries a deadly threat.

Background information: medicine or drug?

According to research, such a drug causes approximately the same feelings that an addict experiences when using heroin. The person feels peaceful and prosperous.

The lyrics are very addictive, even among people who have never used drugs before. This applies to cases when the drug is prescribed as prescribed by a doctor, but it is used with dosage violations, or for too long.

Young people who have become an active user of a new pharmaceutical drug, in the process of numerous experiments with it, have found another dangerous combination. Drinking the lyrics with alcoholic beverages, drug addicts enhance the effect of the remedy. But from a physiological point of view, such a dangerous combination is even more harmful.

Despite the fact that among the general public the lyrics are known only as a new type of narcotic substance, it is primarily a medicine. Its range of activities are:

• reduction of pain syndrome;
• fight against seizures.

The main active ingredient here is pregabalin, which, by the way, is found in the composition of drug analogues. They were also chosen by drug addicts.

A medication aimed at helping with seizures of epilepsy and with a decrease in fighting sensations has found widespread use in relieving withdrawal symptoms (withdrawal symptoms). The medication is one of the many parts of the drug addiction treatment program.

But because of its danger, the lyrics are dispensed strictly by prescription and consumed under the supervision of medical professionals. Bringing relief on the one hand, the medicine cripples on the other.

Contraindications for taking the drug

Drug addicts who liked the analgesic effect of the drug never pay attention to the contraindications in the instructions for the narcotic pills. And even more so, they do not consider the long list of side effects that make themselves felt immediately.

The main contraindications indicated in the factory instructions are:

• appointments for intolerance to the active substance - pregabalin.
• metabolic problems. This is a metabolic disorder closely related to the inability to normally absorb glucose or galactose.
• pathology of the central nervous system (which is usually always followed by experienced drug addicts).
• mental disorders of various types.
• pregnancy and lactation.
• cardiovascular diseases.
• renal failure.
• children up to 17 years old.

At the same time, the developers always warn that the consequences of refusing the drug also take place. They are expressed in the following symptoms:

• sensations like a cold;
• nausea;
• depression;
• disorders of the digestive system;
• increased sweating;
• sense of anxiety.

Experts also warn that even if the patient has no obvious contraindications, this does not mean that he will not be tormented by the consequences of using the lyrics. Almost always, patients are pursued by:

• increased appetite against the background of malfunctions of the digestive tract, up to flatulence.
• dry mouth.
• dryness of the nasal mucosa, accompanied by cough, shortness of breath.
• drops in blood pressure and heart palpitations.
• outflow of blood from the arms and legs (feeling of icy limbs and rush to the head).
• sudden mood swings.
• retardation in behavior, often resulting in complete stupor.
• drowsiness and inability to concentrate.
• fainting and feeling of unreasonable fear.
• trembling limbs.
• problems with the organs of vision.
• profuse sweating.
• rash on the skin.

The unpleasant picture is completed by the fact that a remedy designed to lower the pain threshold for muscle spasms leads the patient to even greater torment during pain in the muscles. It is caused by strong stress.

Even worse, if you start taking lyrics along with medications to suppress nervous reactions. Such a dangerous union often leads the patient to a coma.

Meanwhile, the pharmacological companies themselves insist that such deplorable consequences of the use of lyrics will haunt the victim only if he begins to self-medicate, take the drug uncontrollably at his own discretion, or violate the prescriptions of the attending doctor in every possible way. In a similar situation, it will not be possible to get rid of the above side effects.

Today, pregabalin belongs to the group of dangerous drugs, the drugs on the basis of which are sold only in specialized pharmacies with a prescription from a doctor. But until recently, the lyrics were released to everyone uncontrollably, which led to its massive use and an increase in deaths from its overdose.

The beginning of addiction to lyrics

The fundamental problem associated with the use of lyrics is the inability of most patients to recognize the fact that they have become dependent on it. This idea is based on the fact that many people use it solely for the sake of treatment as part of any restorative therapy. At the same time, patients can often independently prescribe themselves doses higher than necessary, which also negatively affects the state of health.

According to patients, when the dosage is exceeded, they have only one goal - to reduce pain. Each time the consumption rate rises, as the pain has to be suppressed with renewed vigor. Thus, the positive effect of the drug will quickly take on a negative connotation. The danger is added by the fact that the patient does not see his addiction and even denies it in every possible way.

On average, one course of treatment is about 20 days. If for some reason it is required to extend this period (only under the supervision of doctors), then the patient must undergo a detoxification course as an additional treatment. This will help him to quickly cope with the toxic effect of the drug.

At such a time, the patient remains depressed, maintains a depressed mood. This is due to the fact that the nervous system, which is quickly accustomed to the action of the drug, cannot quickly rebuild to the original regime.

According to unofficial statistics, the lyrics are most often taken by those who either used heroin or are still using such drugs. Drug addicts are trying to add new colors to everyday life, using for this another "toy" from the chemical industry.

Signs of an overdose in a patient

Some believe that non-opioid lyrics do not pose a serious danger when used frequently. But in fact, withdrawal withdrawal from lyrics is as excruciating as it is with.

In order to provide timely assistance to the victim of an overdose of this drug, you need to be able to correctly recognize the main symptoms of severe poisoning. It is often expressed in:

• drowsiness
• anxiety,
• dizziness
• irritability,
• depression,
• confused mind;
• drop in vision;
• violation of coordination of movements.

With repeated overdose, panic, speech disorders, as well as sudden mood swings and even hallucinations can be traced.

First aid and hospital aid

As soon as the patient or the people around him notice the first manifestations of the described symptoms, it is necessary to immediately stop taking the medication and inform the doctor about the side effects.

If the poisoning is acute, it will be useful to know how to remove the lyrics from the body as quickly as possible. To do this, call an ambulance, and before her arrival, rinse the sick stomach (only if he is conscious!) At home.

After the patient is admitted to the hospital, he is prescribed supportive therapy with glucose, as well as vitamin supplements intravenously or intramuscularly. Next, hemodialysis is prescribed.

To avoid all this, it is enough to simply adhere to the doctor's recommendations and not engage in the search for dubious pleasures at the expense of your own health.

You and your doctor have decided that you will take Lyrica to treat neuropathic pain. Yes, this is the right choice, because Lyrica is the only special drug for the treatment of pain caused by damage to the nervous system. This brochure will help you better understand how Lyrica works and what you need to know to achieve the best treatment results.

How does Lyrica work?

The lyrics are designed specifically for the treatment of neuropathic pain. Lyrics reduces the amount of "excess" electrical signals that cause pain that travel from damaged nerves to the brain. When you receive Lyrica, the number of these signals gradually decreases and the pain decreases.

What are the indications for Lyrica?

Lyrica is indicated for the treatment of neuropathic pain in adults. Also, the drug is indicated for the treatment of partial epileptic seizures in combination with other antiepileptic drugs.

In what form is Lyrica released?

Lyrica is available in capsules of 75, 150 and 300 mg in packs of 14 and 56 capsules. The manufacturer is PFIZER (USA). It is dispensed in pharmacies according to the usual prescriptions.

How to take Lyrica?

Strictly follow your doctor's recommendations. The doctor should tell you how and what dose to take. The drug is usually taken twice a day: in the morning and in the evening, regardless of the meal. Usually, they start taking with a dosage of 75 mg twice a day and after 3 days the dose is increased to 150 mg 2 times a day. Do not skip taking the drug. When continuing treatment, make sure to purchase the next package to avoid interruption of treatment. Tell your doctor in advance if you decide to stop taking Lyrica.

When to expect pain relief?

First week: start taking and observe the intensity of the pain, Lyrica is a highly effective drug for the treatment of neuropathic pain, but its effect is individual. According to clinical studies, pain relief is noted after 3 days of treatment. During the first week of use, some patients may decrease and disappear completely:

• burning;
• shooting pains;
• throbbing pain;
• tingling.

If you have new discomfort in the body that bothers you, please inform your doctor about it, perhaps this is a side effect of the treatment.

First improvement: the drug has started to work, continue taking.

If the pain has diminished, it means that Lyrica has begun to take effect. Continue to take the drug as recommended by your doctor. Remember, the reaction to the drug is individual. In some patients, it may take more than 3-7 days before the first improvement begins. If you do not feel any improvement after several weeks of therapy, inform your doctor about this, perhaps you are taking the drug in an insufficient dose or you have another disease.

You felt a significant relief: continue taking.

Do not stop taking Lyrica immediately, even if the pain is completely gone. If you stop taking Lyrica yourself, the pain may return. You should strictly adhere to the dosage regimen agreed with your doctor.

Reception of Lyrica is safe: why?

Because:

• the drug was specially developed for the treatment of neuropathic pain;
• the effectiveness of Lyrica has been proven in numerous clinical studies conducted in various countries of the world with the participation of more than 10,000 patients;
• over one million people worldwide take Lyrica for the treatment of neuropathic pain.

What if I missed Lyrica reception?

If you forget to take the drug, and no more than 3-4 hours have passed, then take the missed dose as soon as possible. If there are several hours left before the next dose, then take only the next dose. Do not take a double dose at once instead of the missed tablet. Try to take Lyrica regularly.

Possible side effects

As with other medications, side effects may occur when taking Lyrica. In the conducted studies, the following were most often noted: dizziness, drowsiness, dry mouth, swelling of the hands and feet, blurred vision, slight weight gain, difficulty concentrating. Most often, these phenomena are mild and disappear over time.

Can I take other medicines with Lyrica?

Taking Lyrica with other medications is generally safe. However, tell your doctor about any medications you intend to take, including over-the-counter drugs, vitamins, and herbs.

What should you consider before starting to take Lyrica?

• You should not take Lyrica if pregnancy or conception is planned.
• You should not take Lyrica if you are breastfeeding.
• You should not drive a car until you know how the Lyrics affects you (whether, for example, concentration of attention is not disturbed).
• While taking Lyrica, drinking alcohol can sometimes cause excessive sleepiness.
• Tell your doctor if you have kidney disease.

Pharmacotherapy of pain

• LYRICA (pregabalin) - patient guide